Multiple Endocrine Neoplasia

 Multiple Endocrine Neoplasia,



Type I (MEN-I)--> wermer's syndrome---> MEN1 gene involved
T3P
T hyroid adenoma

P arathyroid
P ituitary
P ancreas (islet cell, ZE syndrome)

Multiple Endocrine Neoplasia, Type IIa (MEN-IIa)---> sippple---> RET gene involved
2PM
P arathyroid
P heochromocytoma
M edullary thyroid carcinoma (MTC-calcitonin)

Multiple Endocrine Neoplasia, Type IIb (MEN-IIa)
2PM MG
P arathyroid
P heochromocytoma
M edullary thyroid carcinoma (MTC-calcitonin)
M arfanoid phenotypes
G anglioneuroma (intestinal and visceral)